Rosetta translates all x86_64 instructions, but it doesn’t support the execution of some newer instruction sets and processor features, such as AVX, AVX2, and AVX512 vector instructions. Virtual Machine apps that virtualize x86_64 computer platforms However, Rosetta doesn’t translate the following executables: Rosetta can translate most Intel-based apps, including apps that contain just-in-time (JIT) compilers. Note specifically this (does Calibre use Kernel extensions?): Here's a link from Apple that describes what is compatible: ![]() In the past calibre has had dual ppc/x86 builds for os x, so its not impossible, just dont expect it to be anytime soon. Cant answer your first question, as to the second, pretty hard, all of calibre's deps would need to be dual compiled.
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